HSRC IR Repository

Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial

Show simple item record

dc.date.accessioned 2020-10-09T07:15:20Z
dc.date.available 2020-10-09T07:15:20Z
dc.date.issued 2020-10-09 en
dc.identifier.uri http://hdl.handle.net/20.500.11910/15476
dc.description.abstract Community-based delivery of antiretroviral therapy (ART) for HIV, including ART initiation, clinical and laboratory monitoring, and refills, could reduce barriers to treatment and improve viral suppression, reducing the gap in access to care for individuals who have detectable HIV viral load, including men who are less likely than women to be virally suppressed. We aimed to test the effect of community-based ART delivery on viral suppression among people living with HIV not on ART. We did a household-randomised, unblinded trial (DO ART) of delivery of ART in the community compared with the clinic in rural and peri-urban settings in KwaZulu-Natal, South Africa and the Sheema District, Uganda. After community-based HIV testing, people living with HIV were randomly assigned (1:1:1) with mobile phone software to community-based ART initiation with quarterly monitoring and ART refills through mobile vans; ART initiation at the clinic followed by mobile van monitoring and refills (hybrid approach); or standard clinic ART initiation and refills. The primary outcome was HIV viral suppression at 12 months. If the difference in viral suppression was not superior between study groups, an a-priori test for non-inferiority was done to test for a relative risk (RR) of more than 0-5. The cost per person virally suppressed was a co-primary outcome of the study. en
dc.format.medium Print en
dc.subject ANTIRETROVIRAL THERAPY en
dc.subject SOUTH AFRICA en
dc.subject UGANDA en
dc.subject HEALTH CARE en
dc.subject HIV/AIDS en
dc.title Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial en
dc.type Journal Article en
dc.description.version Y en
dc.ProjectNumber POYNSA en
dc.Volume 8 en
dc.BudgetYear 2020/21 en
dc.ResearchGroup Impact Centre en
dc.ResearchGroup Developmental, Capable and Ethical State en
dc.ResearchGroup Human and Social Capabilities en
dc.SourceTitle Lancet Global Health en
dc.ArchiveNumber 11578 en
dc.PageNumber 1305-1315 en
dc.outputnumber 10743 en
dc.bibliographictitle Barnabas, R.V., Szpiro, A.A., Van Rooyen, H., Asiimwe, S., Pillay, D., Ware, N.C., Schaafsma, T.T., Krows, M.L., Van Heerden, A., Joseph, P., Shahmanesh, M., Wyatt, M.A., Sausi, K., Turyamureeba, B., Sithole, N., Morrison, S., Shapiro, A.E., Roberts, D.A., Thomas, K.K., Koole, O., Behrsteyn, A., Ehrenkranz, P., Baeten, J.M. & Celum, C. (2020) Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial. <i>Lancet Global Health</i>. 8:1305-1315. en
dc.publicationyear 2020 en
dc.contributor.author1 Barnabas, R.V. en
dc.contributor.author2 Szpiro, A.A. en
dc.contributor.author3 Van Rooyen, H. en
dc.contributor.author4 Asiimwe, S. en
dc.contributor.author5 Pillay, D. en
dc.contributor.author6 Ware, N.C. en
dc.contributor.author7 Schaafsma, T.T. en
dc.contributor.author8 Krows, M.L. en
dc.contributor.author9 Van Heerden, A. en
dc.contributor.author10 Joseph, P. en
dc.contributor.author11 Shahmanesh, M. en
dc.contributor.author12 Wyatt, M.A. en
dc.contributor.author13 Sausi, K. en
dc.contributor.author14 Turyamureeba, B. en
dc.contributor.author15 Sithole, N. en
dc.contributor.author16 Morrison, S. en
dc.contributor.author17 Shapiro, A.E. en
dc.contributor.author18 Roberts, D.A. en
dc.contributor.author19 Thomas, K.K. en
dc.contributor.author20 Koole, O. en
dc.contributor.author21 Behrsteyn, A. en
dc.contributor.author22 Ehrenkranz, P. en
dc.contributor.author23 Baeten, J.M. en
dc.contributor.author24 Celum, C. en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search HSRC IR


Browse

My Account